Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humans.
Identifieur interne : 002465 ( Main/Exploration ); précédent : 002464; suivant : 002466Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humans.
Auteurs : Jamie Purzner [Canada] ; Guillermo O. Paradiso ; Danny Cunic ; Jean A. Saint-Cyr ; Tasnuva Hoque ; Andres M. Lozano ; Anthony E. Lang ; Elena Moro ; Mojgan Hodaie ; Filomena Mazzella ; Robert ChenSource :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- physiology : Basal Ganglia, Cerebellum, Movement, Nerve Net, Reaction Time.
- physiopathology : Parkinson Disease, Tremor.
- Adult, Aged, Cues, Female, Humans, Male, Middle Aged, Motivation.
Abstract
The subthalamic nucleus (STN) is part of the cortico-basal ganglia (BG)-thalamocortical circuit, whereas the ventral lateral nucleus of the thalamus (VL) is a relay nucleus in the cerebello-dentato-thalamocortical (CTC) pathway. Both pathways have been implicated in movement preparation. We compared the involvement of the STN and VL in movement preparation in humans by recording local field potentials (LFPs) from seven patients with Parkinson's disease with deep-brain stimulation (DBS) electrodes in the STN and five patients with tremor and electrodes in VL. LFPs were recorded from DBS electrodes and scalp electrodes simultaneously while the patients performed self-paced and externally cued (ready, go/no-go) movements. For the self-paced movement, a premovement-related potential was observed in all patients from scalp, STN (phase reversal, five of six patients), and VL (phase reversal, five of five patients) electrodes. The onset times of the potentials were similar in the cortex, STN, and VL, ranging from 1.5 to 2 s before electromyogram onset. For the externally cued movement, an expectancy potential was observed in all patients in cortical and STN electrodes (phase reversal, six of six patients). The expectancy potential was recorded from the thalamic electrodes in four of five patients. However, phase reversal occurred only in one case, and magnetic resonance imaging showed that this contact was outside the VL. The cortico-BG-thalamocortical circuit is involved in the preparation of both self-paced and externally cued movements. The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements.
DOI: 10.1523/JNEUROSCI.5441-06.2007
PubMed: 17537974
Affiliations:
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Paradiso</name></author><author><name sortKey="Cunic, Danny" sort="Cunic, Danny" uniqKey="Cunic D" first="Danny" last="Cunic">Danny Cunic</name></author><author><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A" last="Saint-Cyr">Jean A. Saint-Cyr</name></author><author><name sortKey="Hoque, Tasnuva" sort="Hoque, Tasnuva" uniqKey="Hoque T" first="Tasnuva" last="Hoque">Tasnuva Hoque</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17537974</idno><idno type="pmid">17537974</idno><idno type="doi">10.1523/JNEUROSCI.5441-06.2007</idno><idno type="wicri:Area/PubMed/Corpus">001076</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001076</idno><idno type="wicri:Area/PubMed/Curation">001076</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001076</idno><idno type="wicri:Area/PubMed/Checkpoint">001076</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001076</idno><idno type="wicri:Area/Ncbi/Merge">000774</idno><idno type="wicri:Area/Ncbi/Curation">000774</idno><idno type="wicri:Area/Ncbi/Checkpoint">000774</idno><idno type="wicri:Area/Main/Merge">002696</idno><idno type="wicri:Area/Main/Curation">002465</idno><idno type="wicri:Area/Main/Exploration">002465</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humans.</title><author><name sortKey="Purzner, Jamie" sort="Purzner, Jamie" uniqKey="Purzner J" first="Jamie" last="Purzner">Jamie Purzner</name><affiliation wicri:level="1"><nlm:affiliation>The Krembil Neuroscience Centre and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8.</nlm:affiliation><country>Canada</country><wicri:regionArea>The Krembil Neuroscience Centre and Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Paradiso, Guillermo O" sort="Paradiso, Guillermo O" uniqKey="Paradiso G" first="Guillermo O" last="Paradiso">Guillermo O. Paradiso</name></author><author><name sortKey="Cunic, Danny" sort="Cunic, Danny" uniqKey="Cunic D" first="Danny" last="Cunic">Danny Cunic</name></author><author><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A" last="Saint-Cyr">Jean A. Saint-Cyr</name></author><author><name sortKey="Hoque, Tasnuva" sort="Hoque, Tasnuva" uniqKey="Hoque T" first="Tasnuva" last="Hoque">Tasnuva Hoque</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Basal Ganglia (physiology)</term><term>Cerebellum (physiology)</term><term>Cues</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motivation</term><term>Movement (physiology)</term><term>Nerve Net (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Reaction Time (physiology)</term><term>Tremor (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Basal Ganglia</term><term>Cerebellum</term><term>Movement</term><term>Nerve Net</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cues</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motivation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) is part of the cortico-basal ganglia (BG)-thalamocortical circuit, whereas the ventral lateral nucleus of the thalamus (VL) is a relay nucleus in the cerebello-dentato-thalamocortical (CTC) pathway. Both pathways have been implicated in movement preparation. We compared the involvement of the STN and VL in movement preparation in humans by recording local field potentials (LFPs) from seven patients with Parkinson's disease with deep-brain stimulation (DBS) electrodes in the STN and five patients with tremor and electrodes in VL. LFPs were recorded from DBS electrodes and scalp electrodes simultaneously while the patients performed self-paced and externally cued (ready, go/no-go) movements. For the self-paced movement, a premovement-related potential was observed in all patients from scalp, STN (phase reversal, five of six patients), and VL (phase reversal, five of five patients) electrodes. The onset times of the potentials were similar in the cortex, STN, and VL, ranging from 1.5 to 2 s before electromyogram onset. For the externally cued movement, an expectancy potential was observed in all patients in cortical and STN electrodes (phase reversal, six of six patients). The expectancy potential was recorded from the thalamic electrodes in four of five patients. However, phase reversal occurred only in one case, and magnetic resonance imaging showed that this contact was outside the VL. The cortico-BG-thalamocortical circuit is involved in the preparation of both self-paced and externally cued movements. The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Cunic, Danny" sort="Cunic, Danny" uniqKey="Cunic D" first="Danny" last="Cunic">Danny Cunic</name><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name><name sortKey="Hoque, Tasnuva" sort="Hoque, Tasnuva" uniqKey="Hoque T" first="Tasnuva" last="Hoque">Tasnuva Hoque</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Paradiso, Guillermo O" sort="Paradiso, Guillermo O" uniqKey="Paradiso G" first="Guillermo O" last="Paradiso">Guillermo O. Paradiso</name><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A" last="Saint-Cyr">Jean A. Saint-Cyr</name></noCountry><country name="Canada"><noRegion><name sortKey="Purzner, Jamie" sort="Purzner, Jamie" uniqKey="Purzner J" first="Jamie" last="Purzner">Jamie Purzner</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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